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Risk for chronic opioid use can be triggered in as little as three days

Tuesday, May 2, 2017   (0 Comments)
Posted by: Leila Faucette
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Risk for chronic opioid use can be triggered in as little as three days

 
The likelihood of chronic opioid use in patients increased with each additional day of medication supplied starting with the third day and saw sharper increases as time went on, according to research recently published in Morbidity and Mortality Weekly Report:  Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use — United States, 2006–2015

Weekly / March 17, 2017 / 66(10);265–269

Because long-term opioid use often begins with treatment of acute pain (1), in March 2016, the CDC Guideline for Prescribing Opioids for Chronic Pain included recommendations for the duration of opioid therapy for acute pain and the type of opioid to select when therapy is initiated (2). However, data quantifying the transition from acute to chronic opioid use are lacking. Patient records from the IMS Lifelink+ database were analyzed to characterize the first episode of opioid use among commercially insured, opioid-naïve, cancer-free adults and quantify the increase in probability of long-term use of opioids with each additional day supplied, day of therapy, or incremental increase in cumulative dose. The largest increments in probability of continued use were observed after the fifth and thirty-first days on therapy; the second prescription; 700 morphine milligram equivalents cumulative dose; and first prescriptions with 10- and 30-day supplies. By providing quantitative evidence on risk for long-term use based on initial prescribing characteristics, these findings might inform opioid prescribing practices. READ MORE


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